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Passive Care Research
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Theraputic Ultrasound
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1. Forslund, C et al. Effects of high-intensity focused ultrasound on the intervertebral disc: a potential therapy for disc herniations. J Clin Ultrasound. 2006 Sep; 34 (7):330-8.
The purpose of this study was to determine the potential application of high-intensity focused ultrasound for the minimally invasive treatment of herniated intervertebral discs. The study aimed to see if the ultrasound could produce sufficient heat to shrink collagen fibers
- Sufficient temperature increase to produce collagen shrinkage was observed close to the focus of the ultrasound.
- Experiments revealed changes in the disc consistent with collagen shrinkage, with no adverse effects seen in surrounding tissues.
The experiments demonstrated the feasibility of high-intensity focused ultrasound in the treatment of contained herniated discs.
2. Miyamoto, K et al. Exposure to pulsed low intensity ultrasound stimulates extracellular matrix metabolism of bovine intervertebral disc cells cultured in alginate beads. Spine. 2005 Nov 1; 30(21):2398-405.
The objective of this study was to determine whether pulsed low intensity ultrasound has effects on cell proliferation and extracellular matrix metabolism by bovine intervertebral disc cells.
In the ultrasound group, pulsed low intensity ultrasound was administered to the culture for 20 minutes daily for an additional 20 days.
The control group was cultured in the same way but without administration of ultrasound.
The application of pulsed low intensity ultrasound stimulated extracellular matrix metabolism in intervertebral disc cells.
3. Warden SJ, et al. Low-intensity pulsed ultrasound accelerates and a nonsteroidal anti-inflammatory drug delays knee ligament healing. Am J Sports Med. 2006 Jul; 34 (7):1094-102.
Low-intensity pulsed ultrasound and nonsteroidal anti-inflammatory drugs are used to treat ligament injuries; however, their individual and combined effects are not established. This study aimed to see if there were any combined effects of these to methods of treatment, or if one treatment was superior to the other.
- After 2 weeks of intervention, ligaments treated with active low-intensity pulsed ultrasound were 34.2% stronger, 27.0% stiffer, and could absorb 54.4% more energy before failure than could ligaments treated with inactive low-intensity pulsed ultrasound.
- Ligaments from the NSAID group could absorb 33.3% less energy than could ligaments from the group that did not receive the NSAIDS.
Low-intensity pulsed ultrasound accelerated ligament healing, whereas the nonsteroidal anti-inflammatory drug delayed healing.
When used in combination, the beneficial low-intensity pulsed ultrasound effect was cancelled by the detrimental nonsteroidal anti-inflammatory drug effect.
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